Carboxylation of C−H Bonds Using N-Heterocyclic Carbene Gold(I) Complexes

A highly efficient [(NHC)AuI]-based (NHC = N-heterocyclic carbene) catalytic system for the carboxylation of aromatic and heteroaromatic C−H bonds was developed. The significant base strength of the Au−OH species is at the origin of the activation process and permits the facile functionalization of...

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Bibliographic Details
Published inJournal of the American Chemical Society Vol. 132; no. 26; pp. 8858 - 8859
Main Authors Boogaerts, Ine I. F, Nolan, Steven P
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 07.07.2010
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
CHEMOSELECTIVE CARBOXYLATION
ACTIVATION
ACIDS
CARBON-DIOXIDE
CO2
ESTERS
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Summary:A highly efficient [(NHC)AuI]-based (NHC = N-heterocyclic carbene) catalytic system for the carboxylation of aromatic and heteroaromatic C−H bonds was developed. The significant base strength of the Au−OH species is at the origin of the activation process and permits the facile functionalization of C−H bonds without the use of other organometallic reagents.
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ISSN:0002-7863
1520-5126
DOI:10.1021/ja103429q