Verticilactam, a New Macrolactam Isolated from a Microbial Metabolite Fraction Library

Systematic isolation of microbial metabolites has been performed to construct microbial metabolite libraries or fraction libraries. A novel macrolactam, verticilactam (1), was isolated from a library of Streptomyces spiroverticillatus JC-8444. The structure was determined on the basis of NMR and mas...

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Published inOrganic letters Vol. 12; no. 20; pp. 4564 - 4567
Main Authors Nogawa, Toshihiko, Okano, Akiko, Takahashi, Shunji, Uramoto, Masakazu, Konno, Hideaki, Saito, Tamio, Osada, Hiroyuki
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 15.10.2010
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Lactams - chemistry
Lactams - isolation & purification
Lactams - metabolism
Macrolides - chemistry
Macrolides - isolation & purification
Macrolides - metabolism
Models, Molecular
Molecular Structure
Physical Sciences
Science & Technology
Streptomyces - chemistry
Streptomyces - metabolism
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Summary:Systematic isolation of microbial metabolites has been performed to construct microbial metabolite libraries or fraction libraries. A novel macrolactam, verticilactam (1), was isolated from a library of Streptomyces spiroverticillatus JC-8444. The structure was determined on the basis of NMR and mass spectrometric measurements. 1 had a unique 16-membered macrolactam skeleton including a β-keto-amide moiety.
Bibliography:ObjectType-Article-1
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ISSN:1523-7060
1523-7052
DOI:10.1021/ol1018618