CuO-Promoted Construction of N-2-Aryl-Substituted-1,2,3-Triazoles via Azide-Chalcone Oxidative Cycloaddition and Post-Triazole Arylation

An efficient one-pot three-component stepwise approach for the synthesis of N-2-aryl-substituted-1,2,3-triazoles has been developed. By using this azide-chalcone oxidative cycloaddition and post-triazole arylation, a series of N-2-aryl-substituted-1,2,3-triazoles are readily prepared under mild cond...

Full description

Saved in:
Bibliographic Details
Published inOrganic letters Vol. 14; no. 1; pp. 26 - 29
Main Authors Zhang, Yuanqing, Li, Xiaolong, Li, Jihui, Chen, Jinying, Meng, Xu, Zhao, Mingming, Chen, Baohua
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 06.01.2012
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
SODIUM-AZIDE
ONE-POT SYNTHESIS
TERMINAL ACETYLENES
1,2,3-TRIAZOLES
1,3-DIPOLAR CYCLOADDITION
REGIOSELECTIVE SYNTHESIS
EFFICIENT SYNTHESIS
SOLID-PHASE
CLICK-CHEMISTRY
ALKYNE CYCLOADDITION
Online AccessGet full text

Cover

More Information
Summary:An efficient one-pot three-component stepwise approach for the synthesis of N-2-aryl-substituted-1,2,3-triazoles has been developed. By using this azide-chalcone oxidative cycloaddition and post-triazole arylation, a series of N-2-aryl-substituted-1,2,3-triazoles are readily prepared under mild conditions in excellent yields and high regioselectivity. Both the catalyst and substrates are readily available.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1523-7060
1523-7052
DOI:10.1021/ol202718d