A New Enabling Technology for Convenient Laboratory Scale Continuous Flow Processing at Low Temperatures

A new machine for conducting continuous flow processes at low temperatures on a laboratory scale is reported. The use of this cryogenic flow reactor has been demonstrated by the preparation of a variety of (hetero)aromatic boronic acids and esters via lithium halogen exchange chemistry. Furthermore,...

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Published inOrganic letters Vol. 13; no. 13; pp. 3312 - 3315
Main Authors Browne, Duncan L, Baumann, Marcus, Harji, Bashir H, Baxendale, Ian R, Ley, Steven V
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 01.07.2011
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Summary:A new machine for conducting continuous flow processes at low temperatures on a laboratory scale is reported. The use of this cryogenic flow reactor has been demonstrated by the preparation of a variety of (hetero)aromatic boronic acids and esters via lithium halogen exchange chemistry. Furthermore, scale-up of the reaction conditions not only demonstrates the application of this device for the preparation of useful building blocks but also combines the ability to process n-butyllithium directly through pump heads attached to the unit.
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ISSN:1523-7060
1523-7052
DOI:10.1021/ol2010006