Technique for greatly shortening the transition from methadone to naltrexone maintenance of patients addicted to opiates

Acute methadone detoxification was induced by the intravenous administration of naloxone during simultaneous intravenous sedation with midazolam, a fully reversible short-acting benzodiazepine, in seven patients addicted to opiates. Within hours the patients tolerated full doses of naltrexone. This...

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Bibliographic Details
Published inThe American journal of psychiatry Vol. 148; no. 7; p. 933
Main Authors Loimer, N, Lenz, K, Schmid, R, Presslich, O
Format Journal Article
LanguageEnglish
Published United States 01.07.1991
Subjects
Adult
Drug Administration Schedule
Drug Therapy, Combination
Female
Humans
Male
Methadone - administration & dosage
Methadone - therapeutic use
Midazolam - administration & dosage
Midazolam - therapeutic use
Naloxone - therapeutic use
Naltrexone - therapeutic use
Opioid-Related Disorders - prevention & control
Opioid-Related Disorders - rehabilitation
Substance Withdrawal Syndrome - prevention & control
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Summary:Acute methadone detoxification was induced by the intravenous administration of naloxone during simultaneous intravenous sedation with midazolam, a fully reversible short-acting benzodiazepine, in seven patients addicted to opiates. Within hours the patients tolerated full doses of naltrexone. This technique enables patients to transfer easily, quickly, and safely from methadone to naltrexone maintenance.
ISSN:0002-953X
DOI:10.1176/ajp.148.7.933