Pd(II)-Catalyzed Hydroxyl-Directed C−H Activation/C−O Cyclization: Expedient Construction of Dihydrobenzofurans

A Pd(II)-catalyzed C−H activation/C−O cyclization reaction directed by a proximate hydroxyl group has been developed. This reaction provides a new method for constructing dihydrobenzofurans, including spirocyclic analogues, a process that is potentially applicable to natural product synthesis.

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Bibliographic Details
Published inJournal of the American Chemical Society Vol. 132; no. 35; pp. 12203 - 12205
Main Authors Wang, Xisheng, Lu, Yi, Dai, Hui-Xiong, Yu, Jin-Quan
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 08.09.2010
Amer Chemical Soc
Subjects
Benzofurans - chemical synthesis
Benzofurans - chemistry
Catalysis
Chemistry
Chemistry, Multidisciplinary
Cyclization
Hydroxides - chemistry
Molecular Structure
Organometallic Compounds - chemistry
Palladium - chemistry
Physical Sciences
Science & Technology
Stereoisomerism
FUNCTIONALIZATION
ALIPHATIC-ALCOHOLS
IODIDES
AMINATION
HETEROCYCLES
TEMPERATURE
ARYL HALIDES
ARYLATION
INDOLINES
BOND FORMATION
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Summary:A Pd(II)-catalyzed C−H activation/C−O cyclization reaction directed by a proximate hydroxyl group has been developed. This reaction provides a new method for constructing dihydrobenzofurans, including spirocyclic analogues, a process that is potentially applicable to natural product synthesis.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0002-7863
1520-5126
DOI:10.1021/ja105366u