A Ratiometric Fluorescent Probe for Cysteine and Homocysteine Displaying a Large Emission Shift

4-(1H-phenanthro[9,10-d]imidazol-2-yl)benzaldehyde 1 was rationally designed as a novel ratiometric fluorescent probe for cysteine and homocysteine. Upon addition of cysteine or homocysteine, notably, the probe displayed a very large (125 nm) hypsochromic shift in emission due to switching off intra...

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Published inOrganic letters Vol. 10; no. 24; pp. 5577 - 5580
Main Authors Lin, Weiying, Long, Lingliang, Yuan, Lin, Cao, Zengmei, Chen, Bingbing, Tan, Wen
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 18.12.2008
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Cysteine - analysis
Fluorescent Dyes - chemical synthesis
Fluorescent Dyes - chemistry
Homocysteine - analysis
Imidazoles - chemical synthesis
Imidazoles - chemistry
Phenanthrolines - chemical synthesis
Phenanthrolines - chemistry
Physical Sciences
Science & Technology
Spectrometry, Fluorescence
SENSOR
ZINC
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Summary:4-(1H-phenanthro[9,10-d]imidazol-2-yl)benzaldehyde 1 was rationally designed as a novel ratiometric fluorescent probe for cysteine and homocysteine. Upon addition of cysteine or homocysteine, notably, the probe displayed a very large (125 nm) hypsochromic shift in emission due to switching off intramolecular charge transfer. This large emission wavelength shift may allow probe 1 to be employed for quantitatively detecting Cys/Hcy.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1523-7060
1523-7052
DOI:10.1021/ol802436j