Mixed f−d Coordination Complexes as Dual Visible- and Near-Infrared-Emitting Probes for Targeting DNA

A new family of mixed-lanthanide (YbIII and NdIII) transition-metal (f−d) cyclen-RuII(phen)3 (phen = 1,10-phenanthroline) complexes were synthesized as dual visible- and near-infrared (NIR)-emitting DNA probes/sensors. Significant changes were seen in both the RuII visible and the YbIII-centered NIR...

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Published inInorganic chemistry Vol. 48; no. 11; pp. 4646 - 4648
Main Authors Nonat, Aline M, Quinn, Susan J, Gunnlaugsson, Thorfinnur
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 01.06.2009
Subjects
DNA - chemistry
DNA Probes - chemistry
Lanthanoid Series Elements - chemistry
Molecular Structure
Organometallic Compounds - chemical synthesis
Organometallic Compounds - chemistry
Ruthenium - chemistry
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Summary:A new family of mixed-lanthanide (YbIII and NdIII) transition-metal (f−d) cyclen-RuII(phen)3 (phen = 1,10-phenanthroline) complexes were synthesized as dual visible- and near-infrared (NIR)-emitting DNA probes/sensors. Significant changes were seen in both the RuII visible and the YbIII-centered NIR emission, which was switched off upon binding to DNA at pH 7.4. In contrast, no changes were seen in the NdIII emission of the analogue f−d conjugate.
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ISSN:0020-1669
1520-510X
DOI:10.1021/ic900422z