Cigarette Smoking and Urinary 3-Alkyladenine Excretion in Man
A recently developed technique to measure several 3-alkyladenines (3-alkAde) simultaneously in urine has been applied to study alkylating agent exposure arising from cigarette smoke. A volunteer who was a moderate smoker (10−32 cigarettes per day) excreted significantly more 3-methyladenine (3-MeAde...
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Published in | Chemical research in toxicology Vol. 9; no. 2; pp. 439 - 444 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
United States
American Chemical Society
01.03.1996
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Subjects | |
Online Access | Get full text |
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Summary: | A recently developed technique to measure several 3-alkyladenines (3-alkAde) simultaneously in urine has been applied to study alkylating agent exposure arising from cigarette smoke. A volunteer who was a moderate smoker (10−32 cigarettes per day) excreted significantly more 3-methyladenine (3-MeAde) on days when he smoked than when he did not smoke. In contrast, there was no significant difference in 3-MeAde excretion in a light smoker (less than 17 cigarettes per day) on smoking compared to nonsmoking days. However, in volunteers who consumed a standardized diet low in preformed 3-MeAde, there was a smoking-related increase in 3-MeAde excretion even at low levels of cigarette use (less than 11 cigarettes per day). In the same volunteers, no evidence of smoking-related excretion of 3-(2-hydroxyethyl)adenine could be seen. In contrast, levels of urinary 3-ethyladenine (3-EtAde) increased slightly in smokers on standardized diets. Furthermore, since the normal background level of 3-EtAde was low, an exposure-dependent increase in this adduct was seen in two smokers on free-choice diets over a 15 day period. The agent(s) responsible for the increase in 3-EtAde excretion have not been identified, but preliminary results suggest that a direct-acting ethylating compound is present in tobacco smoke. |
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Bibliography: | Abstract published in Advance ACS Abstracts, February 1, 1996. ark:/67375/TPS-PKG954MD-N istex:5337976884A63304A271AD1CC10038E2CCC7E338 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0893-228X 1520-5010 |
DOI: | 10.1021/tx9501041 |