[(NHC)AuI]-Catalyzed Acid-Free Alkyne Hydration at Part-per-Million Catalyst Loadings

A highly efficient [(NHC)AuI]-based (NHC = N-heterocyclic carbene) catalytic system for the hydration of an array of alkynes that operates under acid-free conditions and at very low catalyst loadings (typically 50−100 ppm and as low as 10 ppm) was developed. Terminal and internal alkynes possessing...

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Bibliographic Details
Published inJournal of the American Chemical Society Vol. 131; no. 2; pp. 448 - 449
Main Authors Marion, Nicolas, Ramón, Rubén S, Nolan, Steven P
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 21.01.2009
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
GOLD(III)
GOLD
KETONES
HETEROCYCLIC CARBENES
HIGHLY EFFICIENT CATALYSTS
COMPLEXES
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Summary:A highly efficient [(NHC)AuI]-based (NHC = N-heterocyclic carbene) catalytic system for the hydration of an array of alkynes that operates under acid-free conditions and at very low catalyst loadings (typically 50−100 ppm and as low as 10 ppm) was developed. Terminal and internal alkynes possessing any combination of alkyl and aryl substituents (alkyl/H, aryl/H, alkyl/alkyl, alkyl/aryl, and aryl/aryl) were found suitable substrates in the present catalytic system.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0002-7863
1520-5126
DOI:10.1021/ja809403e