Convenient Preparation and Use of a New Analytical Construct for the Analysis and Development of Solid-Phase Chemistries

An expedient and scalable synthesis of a versatile new analytical construct intermediate 1 is described. The utility of the intermediate 1 is exemplified by the preparation of the construct resin 14 incorporating an acid-labile linker which is used to conveniently develop optimized conditions leadin...

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Bibliographic Details
Published inJournal of organic chemistry Vol. 68; no. 14; pp. 5525 - 5533
Main Authors Andrews, Stephen P, Ladlow, Mark
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 11.07.2003
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Exact sciences and technology
Organic chemistry
Physical Sciences
Science & Technology
LIBRARIES
ORGANIC-SYNTHESIS
SAFETY-CATCH LINKER
FRAGMENTS
ACIDS
RESINS
Nitro compound
Sulfone
Combinatorial chemistry
Carboxamide
Aromatic compound
Solid phase
Aldehyde
Chemical synthesis
Anthracene derivatives
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Summary:An expedient and scalable synthesis of a versatile new analytical construct intermediate 1 is described. The utility of the intermediate 1 is exemplified by the preparation of the construct resin 14 incorporating an acid-labile linker which is used to conveniently develop optimized conditions leading to the preparation of a small compound array 24{1 − 3,1 − 3}. The optimized conditions are shown to work equally well on both the construct resin 14 and the corresponding base resin 15.
Bibliography:istex:D04C909E69C10CF439277CACB9E918C90A7FDDC8
ark:/67375/TPS-1ZLJ015Q-P
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0022-3263
1520-6904
DOI:10.1021/jo034340p