Lewis Acid- and Organocatalyst-Cocatalyzed Multicomponent Reactions of 2-Alkynylbenzaldehydes, Amines, and Ketones

One-pot combination of silver triflate and proline catalysis is highly effective for the synthesis of 1,2-dihydroisoquinoline derivatives via multicomponent reactions of 2-alkynylbenzaldehydes, amines, and ketones.

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Bibliographic Details
Published inOrganic letters Vol. 9; no. 24; pp. 4959 - 4962
Main Authors Ding, Qiuping, Wu, Jie
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 22.11.2007
Amer Chemical Soc
Subjects
Amines - chemistry
Benzaldehydes - chemistry
Catalysis
Chemistry
Chemistry, Organic
Isoquinolines - chemical synthesis
Isoquinolines - chemistry
Ketones - chemistry
Mesylates - chemistry
Molecular Structure
Physical Sciences
Proline - chemistry
Science & Technology
ASYMMETRIC-SYNTHESIS
O-ALKYNYLBENZALDEHYDES
3-COMPONENT REACTION
TERMINAL ACETYLENES
SYNTHETIC METHOD
TRANSITION-METAL
ALLYLIC ALKYLATION
TANDEM NUCLEOPHILIC-ADDITION
2-COMPONENT CATALYST SYSTEM
CYCLIZATION
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Summary:One-pot combination of silver triflate and proline catalysis is highly effective for the synthesis of 1,2-dihydroisoquinoline derivatives via multicomponent reactions of 2-alkynylbenzaldehydes, amines, and ketones.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1523-7060
1523-7052
DOI:10.1021/ol7020669