Preparation, Physical Properties, On-Bead Binding Assay and Spectroscopic Reliability of 25 Barcoded Polystyrene−Poly(ethylene glycol) Graft Copolymers

• Published in: Journal of the American Chemical Society Vol. 125; no. 35; pp. 10546 - 10560
• Main Authors: Fenniri, Hicham, Chun, Sangki, Ding, Lunhan, Zyrianov, Yegor, Hallenga, Klaas
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 03.09.2003
• Subjects: Applied sciences; Exact sciences and technology; Organic polymers; Physicochemistry of polymers; Properties and characterization; Special properties (catalyst, reagent or carrier); Alkaline phosphatase; Graft copolymer; Phosphoric monoester hydrolases; Combinatorial chemistry; Molecular interaction; Esterases; NMR spectrometry; Styrene derivative copolymer; Grafting; Characterization; Hydrogen 1; Styrene derivatives; Raman spectrometry; Chemical properties; Reaction support; Suspension polymerization; Carbon 13; Differential scanning calorimetry; Swelling; Enzyme; Ethylene oxide copolymer; Physical properties; Latex; Infrared spectrometry; Preparation; Hydrolases; Property structure relationship; Peptide synthesis; Spectrophotometry

Here we describe the preparation of 25 beaded polystyrene−poly(ethylene glycol) graft copolymers from six spectroscopically active styrene monomers:  styrene, 2,5-dimethylstyrene, 4-methylstyrene, 2,4-dimethylstyrene, 4-tert-butylstyrene, and 3-methylstyrene. These polymers were thoroughly character...