Monodispersed Polymeric Nanocapsules: Spontaneous Evolution and Morphology Transition from Reducible Hetero-PEG PICmicelles by Controlled Degradation

In this communication, a novel “self-templating” strategy was used to prepare uniform and biocompatible nanocapsules by the addition of a reduction agent (i.e., DTT) into a solution of highly monodispersed PICmicelles bearing a heterodetachable PEG corona. PEG chains were released from PICmicelle sh...

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Bibliographic Details
Published inJournal of the American Chemical Society Vol. 131; no. 11; pp. 3804 - 3805
Main Authors Dong, Wen-Fei, Kishimura, Akihiro, Anraku, Yasutaka, Chuanoi, Sayan, Kataoka, Kazunori
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 25.03.2009
Subjects
Biocompatible Materials - chemistry
Disulfides - chemistry
Liposomes
Micelles
Nanocapsules - chemistry
Phase Transition
Polyethylene Glycols - chemistry
Polymers
Reducing Agents
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Summary:In this communication, a novel “self-templating” strategy was used to prepare uniform and biocompatible nanocapsules by the addition of a reduction agent (i.e., DTT) into a solution of highly monodispersed PICmicelles bearing a heterodetachable PEG corona. PEG chains were released from PICmicelle shells following disulfide reduction which leads a spontaneous and drastic morphology evolution from micelles to vesicles induced by the decrease of the PEG weight fraction. Formation of uniform nanocapsules with controllable capsule size was achieved by careful control of the micelle composition and molecular weight of homo-P[Asp(DET)].
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0002-7863
1520-5126
DOI:10.1021/ja808419b