A Simple Catalytic Method for the Regioselective Halogenation of Arenes

This paper describes a mild palladium-catalyzed method for the regioselective chlorination, bromination, and iodination of arene C−H bonds using N-halosuccinimides as oxidants. These transformations have been applied to a wide array of substrates and can provide products that are complementary to th...

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Bibliographic Details
Published inOrganic letters Vol. 8; no. 12; pp. 2523 - 2526
Main Authors Kalyani, Dipannita, Dick, Allison R, Anani, Waseem Q, Sanford, Melanie S
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 08.06.2006
Amer Chemical Soc
Subjects
Catalysis
Chemistry
Chemistry, Organic
Hydrocarbons, Halogenated - chemical synthesis
Molecular Structure
Palladium - chemistry
Physical Sciences
Polycyclic Aromatic Hydrocarbons - chemistry
Science & Technology
Stereoisomerism
PALLADIUM
METALATION
BROMINATION
ARYL HALIDES
COMPLEXES
COPPER
ORTHO-ARYLATION
C-H ACTIVATION
AROMATIC-COMPOUNDS
ULLMANN
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Summary:This paper describes a mild palladium-catalyzed method for the regioselective chlorination, bromination, and iodination of arene C−H bonds using N-halosuccinimides as oxidants. These transformations have been applied to a wide array of substrates and can provide products that are complementary to those obtained via conventional electrophilic aromatic substitution reactions.
Bibliography:Medline
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ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1523-7060
1523-7052
DOI:10.1021/ol060747f