Kinetic Study of Various Phosphoramidite Ligands in the Iridium-Catalyzed Allylic Substitution

A comparative kinetic study of seven ligands is presented which clearly shows that a slight difference in the substitution pattern of the aryl group on the amine moiety of the ligand dramatically alters the activity of the resulting iridium catalyst. Ligand L6 shows the most impressive kinetics as w...

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Bibliographic Details
Published inOrganic letters Vol. 7; no. 8; pp. 1621 - 1624
Main Authors Polet, Damien, Alexakis, Alexandre
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 14.04.2005
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
AMINATION
COMPLEX
ASYMMETRIC-SYNTHESIS
ALKYLATION
ACETATES
PHOSPHORUS AMIDITES
ETHERIFICATION
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Summary:A comparative kinetic study of seven ligands is presented which clearly shows that a slight difference in the substitution pattern of the aryl group on the amine moiety of the ligand dramatically alters the activity of the resulting iridium catalyst. Ligand L6 shows the most impressive kinetics as well as the highest enantioselectivities.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1523-7060
1523-7052
DOI:10.1021/ol050350w