Antifungal Stilbenoids from Stemona collinsae

• Published in: Journal of natural products (Washington, D.C.) Vol. 65; no. 6; pp. 820 - 827
• Main Authors: Pacher, T, Seger, C, Engelmeier, D, Vajrodaya, S, Hofer, O, Greger, H
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 01.06.2002; Amer Chemical Soc; American Society of Pharmacognosy
• Subjects: Alternaria - drug effects; Antifungal Agents - chemistry; Antifungal Agents - isolation & purification; Antifungal Agents - pharmacology; Benzofurans - chemistry; Benzofurans - isolation & purification; Benzofurans - pharmacology; Biological and medical sciences; Botrytis - drug effects; Chemistry, Medicinal; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Cladosporium - drug effects; Furans - chemistry; Furans - isolation & purification; Furans - pharmacology; Fusarium - drug effects; General pharmacology; Life Sciences & Biomedicine; Magnetic Resonance Spectroscopy; Medical sciences; Molecular Structure; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Plant Roots - chemistry; Plant Sciences; Plants, Medicinal - chemistry; Science & Technology; Stilbenes - chemistry; Stilbenes - isolation & purification; Stilbenes - pharmacology; Thailand; Thailand; Asia; 2-ARYLBENZOFURAN PHYTOALEXIN; NATURAL-PRODUCTS; 9,10-DIHYDROPHENANTHRENES; Monocotyledones; Botrytis cinerea; Stemonaceae; Oxygen heterocycle; Diphenols; Medicinal plant; Fungi; Fusarium avenaceum; Antifungal agent; Cladosporium herbarum; Angiospermae; Bicyclic compound; Aromatic compound; Fungi Imperfecti; Thallophyta; Pyricularia grisea; Ether; Root; Pharmacognosy; In vitro; Biological activity; Stilbene derivatives; Alternaria citri; Plant origin; Phenols; Benzenic compound; Isolation; Spermatophyta; Benzofuran derivatives; Structural analysis
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np0105073

Fifteen new stilbenoids including 11 phenylbenzofurans, the stemofurans A−K (1−11), and four dihydrostilbenes, the stilbostemins A (15), C (17), E (19), and F (20), were isolated and identified from a methanolic extract of Stemona collinsae roots together with five known derivatives, the stilbenes pinosylvin (13) and 4‘-methylpinosylvin (14), the dihydrostilbenes, stilbostemins B (16) and D (18), and the dihydrophenanthrene racemosol (12) as well as (+)-sesamin, coniferyl alcohol, and stigmasterol. Bioautographic tests with Cladosporium herbarum displayed antifungal activity for stilbenoids of all four structural types. Ten derivatives were tested against five microfungi using the microdilution technique linked with digital image analysis of germ tubes.