Vinylation of Aryl Bromides Using an Inexpensive Vinylpolysiloxane

A mild and general method for the palladium-catalyzed vinylation of aryl bromides has been developed. The use of tetrabutylammonium fluoride (TBAF) as the activator and an inexpensive and nontoxic vinyl donor, 1,3,5,7-tetramethyl-1,3,5,7-tetravinylcyclotetrasiloxane (D4 V, 1), allows for a general a...

Full description

Saved in:
Bibliographic Details
Published inOrganic letters Vol. 8; no. 1; pp. 63 - 66
Main Authors Denmark, Scott E, Butler, Christopher R
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 05.01.2006
Amer Chemical Soc
Subjects
Bromides - chemistry
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
Siloxanes - chemistry
Styrenes - chemical synthesis
HALIDES
STYRENES
CROSS-COUPLING REACTIONS
REAGENTS
ACIDS
CATALYST
EFFICIENT
Online AccessGet full text

Cover

More Information
Summary:A mild and general method for the palladium-catalyzed vinylation of aryl bromides has been developed. The use of tetrabutylammonium fluoride (TBAF) as the activator and an inexpensive and nontoxic vinyl donor, 1,3,5,7-tetramethyl-1,3,5,7-tetravinylcyclotetrasiloxane (D4 V, 1), allows for a general and high-yielding preparation of substituted styrenes.
Bibliography:Medline
NIH RePORTER
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1523-7060
1523-7052
DOI:10.1021/ol052517r