An Approach to Thermodynamically Controlled Supramolecular Assembly Possessing an Integral Locking Mechanism

A general approach for thermodynamically controlled molecular assembly employing carbonyl addition chemistry is exemplified with a prototypical rotaxane synthesis. Recognition−driven assembly of the rotaxane proceeds under conditions of mild base catalysis, while subsequent treatment with catalytic...

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Bibliographic Details
Published inJournal of the American Chemical Society Vol. 131; no. 3; pp. 902 - 903
Main Authors Cagulada, Amy M, Hamilton, Darren G
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 28.01.2009
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
CHEMISTRY
BINDING
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Summary:A general approach for thermodynamically controlled molecular assembly employing carbonyl addition chemistry is exemplified with a prototypical rotaxane synthesis. Recognition−driven assembly of the rotaxane proceeds under conditions of mild base catalysis, while subsequent treatment with catalytic acid triggers a dehydrative locking mechanism and fixes the evolved molecular architecture in place.
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ISSN:0002-7863
1520-5126
DOI:10.1021/ja808162b