Detection of Unusual Lipid Mixing in Cholesterol-Rich Phospholipid Bilayers:  The Long and the Short of It

• Published in: Journal of the American Chemical Society Vol. 125; no. 30; pp. 8994 - 8995
• Main Authors: Tokutake, Nobuya, Jing, Bingwen, Regen, Steven L
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 30.07.2003; Amer Chemical Soc
• Subjects: Biological and medical sciences; Biological membranes; Chemistry; Chemistry, Multidisciplinary; Cholesterol - chemistry; Colloidal state and disperse state; Exact sciences and technology; Fundamental and applied biological sciences. Psychology; General and physical chemistry; Kinetics; Lipid Bilayers - chemistry; Membrane physicochemistry; Molecular biophysics; Phospholipids - chemistry; Physical and chemical studies. Granulometry. Electrokinetic phenomena; Physical Sciences; Science & Technology; Sterols - chemistry; MEMBRANES; RAFTS; NEAREST-NEIGHBOR RECOGNITION; CELL BIOLOGY; Equilibrium constant; Mixed bilayer; Phospholipid; Sphingolipid; Composition effect; Chemical properties; Experimental study; Phosphorus Organic compounds; Cholesterol
• ISSN: 0002-7863; 1520-5126
• DOI: 10.1021/ja0359355

Nearest-neighbor recognition studies have revealed that favored sterol−phospholipid associations can be reversed in a fluid bilayer that contains relatively long (high melting) and short (low melting) phospholipids, when the sterol content is sufficiently high; that is, like-lipids now become favored nearest-neighbors. A possible origin of this effect is briefly discussed.