Multivalent Protein Binding and Precipitation by Self-Assembling Molecules on a DNA Pentaplex Scaffold

A supramolecular assembly containing an isoguanosine pentaplex with both a “protein-binding” face and a “reporter” face has been generated. When phosphocholine is appended to the protein-binding face this supramolecular assembly binds multivalently to the pentameric human C-reactive protein, a biomo...

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Published inJournal of the American Chemical Society Vol. 131; no. 14; pp. 5020 - 5021
Main Authors Rosenzweig, Brooke A, Ross, Nathan T, Tagore, Debarati M, Jayawickramarajah, Janarthanan, Saraogi, Ishu, Hamilton, Andrew D
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 15.04.2009
Amer Chemical Soc
Subjects
C-Reactive Protein - chemistry
C-Reactive Protein - metabolism
Carrier Proteins
Chemical Precipitation
Chemistry
Chemistry, Multidisciplinary
DNA - chemistry
DNA - metabolism
Enzyme-Linked Immunosorbent Assay
Humans
Light
Phosphorylcholine - chemistry
Phosphorylcholine - metabolism
Physical Sciences
Scattering, Radiation
Science & Technology
C-REACTIVE PROTEIN
TOXINS
FRAGMENTS
LIGAND-BINDING
QUADRUPLEX
INHIBITORS
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Summary:A supramolecular assembly containing an isoguanosine pentaplex with both a “protein-binding” face and a “reporter” face has been generated. When phosphocholine is appended to the protein-binding face this supramolecular assembly binds multivalently to the pentameric human C-reactive protein, a biomolecule implicated in inflammation and heart disease.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0002-7863
1520-5126
DOI:10.1021/ja809219p