Multivalent Protein Binding and Precipitation by Self-Assembling Molecules on a DNA Pentaplex Scaffold
A supramolecular assembly containing an isoguanosine pentaplex with both a “protein-binding” face and a “reporter” face has been generated. When phosphocholine is appended to the protein-binding face this supramolecular assembly binds multivalently to the pentameric human C-reactive protein, a biomo...
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Published in | Journal of the American Chemical Society Vol. 131; no. 14; pp. 5020 - 5021 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
WASHINGTON
American Chemical Society
15.04.2009
Amer Chemical Soc |
Subjects | |
Online Access | Get full text |
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Summary: | A supramolecular assembly containing an isoguanosine pentaplex with both a “protein-binding” face and a “reporter” face has been generated. When phosphocholine is appended to the protein-binding face this supramolecular assembly binds multivalently to the pentameric human C-reactive protein, a biomolecule implicated in inflammation and heart disease. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0002-7863 1520-5126 |
DOI: | 10.1021/ja809219p |