Cobalt-Catalyzed Carbonylation of C(sp2)–H Bonds with Azodicarboxylate as the Carbonyl Source

A novel and efficient approach for the C­(sp2)–H bond carbonylation of benzamides has been developed using stable and inexpensive Co­(OAc)2·4H2O as the catalyst and the commercially available and easily handling azodicarboxylates as the nontoxic carbonyl source. A broad range of substrates bearing d...

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Bibliographic Details
Published inOrganic letters Vol. 18; no. 22; pp. 5960 - 5963
Main Authors Ni, Jiabin, Li, Jie, Fan, Zhoulong, Zhang, Ao
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 18.11.2016
Amer Chemical Soc
Subjects
benzamides
catalysts
chemical reactions
Chemistry
Chemistry, Organic
cobalt
moieties
Physical Sciences
Science & Technology
FUNCTIONALIZATION
ACTIVATION
AMINATION
C-H BOND
ANNULATION
ARENES
TERMINAL ALKYNES
ETHOXYCARBONYLATION
ACCESS
AMIDES
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Summary:A novel and efficient approach for the C­(sp2)–H bond carbonylation of benzamides has been developed using stable and inexpensive Co­(OAc)2·4H2O as the catalyst and the commercially available and easily handling azodicarboxylates as the nontoxic carbonyl source. A broad range of substrates bearing diverse functional groups were tolerated. This is the first example where cobalt-catalyzed C­(sp2)–H bond carbonylation occurs with azodicarboxylate as the carbonyl source.
Bibliography:ObjectType-Article-1
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content type line 23
ISSN:1523-7060
1523-7052
1523-7052
DOI:10.1021/acs.orglett.6b03111