The Role of Charge Distribution on the Antimalarial Activity of Artemisinin Analogues

• Published in: Journal of chemical information and modeling Vol. 45; no. 2; pp. 366 - 370
• Main Authors: Rafiee, Marjan A, Hadipour, Nasser L, Naderi-manesh, Hossein
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 01.03.2005
• Subjects: Alkylation; Antimalarials - chemistry; Antimalarials - pharmacology; Artemisinins - chemistry; Artemisinins - pharmacology; Cations, Divalent - chemistry; Charged particles; Density; Effects; Electrons; Halogens - chemistry; Heme - chemistry; Heme - metabolism; Ions - chemistry; Ions - metabolism; Magnetic Resonance Spectroscopy; Malaria; Molecular Structure; Nitrogen Dioxide - chemistry; Oxidation-Reduction; Sesquiterpenes - chemistry; Sesquiterpenes - pharmacology; Static Electricity; Stereoisomerism
• ISSN: 1549-9596; 1549-960X
• DOI: 10.1021/ci049812v

In this work the calculated nuclear quadrupole coupling constants (NQCC; χ) of 17O in artemisinin and some of its derivatives and the effects of charge density due to the nature of ligands on NQCC of 17O were investigated. All calculations were performed at the HF/3-21G level using the Gaussian 98 program. The results show that the O−O linkage has a characteristic role in the antimalarial activity of artemisinin. In addition, various substitutions on C4 change the charge density on these oxygens and consequently change the pharmaceutical effect of artemisinin. Our results suggest that due to a larger charge density on O1, the heme iron approaches the endoperoxide moiety at the O1 position with preference to the O2 position.