Production of Aromatic Minimal Polyketides by the Daunorubicin Polyketide Synthase Genes Reveals the Incompatibility of the Heterologous DpsY and JadI Cyclases
Our investigations into whether the biosynthesis of a linearly fused ring system of an aromatic polyketide (jadomycin) could be modified to produce an angularly fused system (daunorubicin) and vice versa showed that introduction of the respective cyclases did not have the desired effect. Genes from...
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Published in | Journal of natural products (Washington, D.C.) Vol. 64; no. 8; pp. 1077 - 1080 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
WASHINGTON
American Chemical Society
01.08.2001
Amer Chemical Soc American Society of Pharmacognosy |
Subjects | |
Online Access | Get full text |
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Summary: | Our investigations into whether the biosynthesis of a linearly fused ring system of an aromatic polyketide (jadomycin) could be modified to produce an angularly fused system (daunorubicin) and vice versa showed that introduction of the respective cyclases did not have the desired effect. Genes from the daunorubicin pathway produced a novel 21-carbon polyketide. |
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Bibliography: | ark:/67375/TPS-SFGTMS30-M istex:60B32B2A8C7FC7BC8CB42D3A46595D842C592427 Medline NIH RePORTER ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0163-3864 1520-6025 |
DOI: | 10.1021/np010067f |