Rare-Earth Y(OTf)3 Catalyzed Coupling Reaction of Ethers with Azaarenes

Rare-earth catalysis has become a hot topic in the field of catalytic organic reaction. Chain ethers mostly have lower reactivity and lower boiling points which limited their reaction scope. Herein, we found a rare-earth Y­(OTf)3 can catalyze the coupling reaction of ethers especially chain ethers a...

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Published inOrganic letters Vol. 21; no. 18; pp. 7450 - 7454
Main Authors Wu, Yue-Hua, Wang, Nai-Xing, Zhang, Tong, Zhang, Lei-Yang, Gao, Xue-Wang, Xu, Bao-Cai, Xing, Yalan, Chi, Jian-Yi
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 20.09.2019
Amer Chemical Soc
Subjects
boiling point
catalytic activity
chemical reactions
chemical structure
Chemistry
Chemistry, Organic
ethers
Physical Sciences
rare earth elements
Science & Technology
ACTIVATION
ACIDS
ALKYLATION
ESTERIFICATION
ALPHA
CYCLIC ETHERS
C(SP)-H
BOND
DIRECT ALKYNYLATION
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Summary:Rare-earth catalysis has become a hot topic in the field of catalytic organic reaction. Chain ethers mostly have lower reactivity and lower boiling points which limited their reaction scope. Herein, we found a rare-earth Y­(OTf)3 can catalyze the coupling reaction of ethers especially chain ethers and thioethers with azaarenes. This protocol features simple operations, a broad substrate scope (31 examples), moderate to good yields (up to 85%), and atom economy.
Bibliography:ObjectType-Article-1
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content type line 23
ISSN:1523-7060
1523-7052
1523-7052
DOI:10.1021/acs.orglett.9b02763