Aspterpenacids A and B, Two Sesterterpenoids from a Mangrove Endophytic Fungus Aspergillus terreus H010

Two new sesterterpenoids, aspterpenacids A (1) and B (2), with an unusual carbon skeleton of a 5/3/7/6/5 ring system were isolated from the mangrove endophytic fungus Aspergillus terreus H010. Their structures were elucidated on the basis of spectroscopic methods, single-crystal X-ray diffraction an...

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Published inOrganic letters Vol. 18; no. 6; pp. 1406 - 1409
Main Authors Liu, Zhaoming, Chen, Yan, Chen, Senhua, Liu, Yayue, Lu, Yongjun, Chen, Dongni, Lin, Yongcheng, Huang, Xishan, She, Zhigang
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 18.03.2016
Amer Chemical Soc
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Abstract Two new sesterterpenoids, aspterpenacids A (1) and B (2), with an unusual carbon skeleton of a 5/3/7/6/5 ring system were isolated from the mangrove endophytic fungus Aspergillus terreus H010. Their structures were elucidated on the basis of spectroscopic methods, single-crystal X-ray diffraction analysis, and electronic circular dichroism calculations. A biogenetic pathway for 1 and 2 is proposed. Both 1 and 2 showed no significant antibacterial activity or cytotoxicity at 50 μM.
AbstractList Two new sesterterpenoids, aspterpenacids A (1) and B (2), with an unusual carbon skeleton of a 5/3/7/6/5 ring system were isolated from the mangrove endophytic fungus Aspergillus terreus H010. Their structures were elucidated on the basis of spectroscopic methods, single-crystal X-ray diffraction analysis, and electronic circular dichroism calculations. A biogenetic pathway for 1 and 2 is proposed. Both 1 and 2 showed no significant antibacterial activity or cytotoxicity at 50 μM.
Two new sesterterpenoids, aspterpenacids A (1) and B (2), with an unusual carbon skeleton of a 5/3/7/6/5 ring system were isolated from the mangrove endophytic fungus Aspergillus terreus H010. Their structures were elucidated on the basis of spectroscopic methods, single-crystal X-ray diffraction analysis, and electronic circular dichroism calculations. A biogenetic pathway for 1 and 2 is proposed. Both 1 and 2 showed no significant antibacterial activity or cytotoxicity at 50 μM.Two new sesterterpenoids, aspterpenacids A (1) and B (2), with an unusual carbon skeleton of a 5/3/7/6/5 ring system were isolated from the mangrove endophytic fungus Aspergillus terreus H010. Their structures were elucidated on the basis of spectroscopic methods, single-crystal X-ray diffraction analysis, and electronic circular dichroism calculations. A biogenetic pathway for 1 and 2 is proposed. Both 1 and 2 showed no significant antibacterial activity or cytotoxicity at 50 μM.
Two new sesterterpenoids, aspterpenacids A (1) and B (2), with an unusual carbon skeleton of a 5/3/7/6/5 ring system were isolated from the mangrove endophytic fungus Aspergillus terreus H010. Their structures were elucidated on the basis of spectroscopic methods, single crystal X-ray diffraction analysis, and electronic circular dichroism calculations. A biogenetic pathway for 1 and 2 is proposed. Both 1 and 2 showed no significant antibacterial activity or cytotoxicity at 50 mu M.
Author Liu, Zhaoming
Chen, Senhua
Lu, Yongjun
Huang, Xishan
Liu, Yayue
Lin, Yongcheng
Chen, Yan
Chen, Dongni
She, Zhigang
AuthorAffiliation School of Life Sciences and Biomedical Center
Key Laboratory of Functional Molecules from Oceanic Microorganism, Department of Education of Guangdong Province
School of Chemistry and Chemical Engineering
Sun Yat-Sen University
AuthorAffiliation_xml – name: School of Chemistry and Chemical Engineering
– name: Key Laboratory of Functional Molecules from Oceanic Microorganism, Department of Education of Guangdong Province
– name: Sun Yat-Sen University
– name: School of Life Sciences and Biomedical Center
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Snippet Two new sesterterpenoids, aspterpenacids A (1) and B (2), with an unusual carbon skeleton of a 5/3/7/6/5 ring system were isolated from the mangrove endophytic...
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SubjectTerms Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
antibacterial properties
Aspergillus - chemistry
Aspergillus terreus
carbon
chemical reactions
chemical structure
Chemistry
Chemistry, Organic
Circular Dichroism
circular dichroism spectroscopy
Crystallography, X-Ray
cytotoxicity
endophytes
fungi
Molecular Structure
organic compounds
Physical Sciences
Rhizophoraceae - microbiology
Science & Technology
Sesterterpenes - chemistry
Sesterterpenes - isolation & purification
Sesterterpenes - pharmacology
X-ray diffraction
Title Aspterpenacids A and B, Two Sesterterpenoids from a Mangrove Endophytic Fungus Aspergillus terreus H010
URI http://dx.doi.org/10.1021/acs.orglett.6b00336
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https://www.ncbi.nlm.nih.gov/pubmed/26938636
https://www.proquest.com/docview/1774530505
https://www.proquest.com/docview/2020875339
Volume 18
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