Aspterpenacids A and B, Two Sesterterpenoids from a Mangrove Endophytic Fungus Aspergillus terreus H010

• Published in: Organic letters Vol. 18; no. 6; pp. 1406 - 1409
• Main Authors: Liu, Zhaoming, Chen, Yan, Chen, Senhua, Liu, Yayue, Lu, Yongjun, Chen, Dongni, Lin, Yongcheng, Huang, Xishan, She, Zhigang
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 18.03.2016; Amer Chemical Soc
• Subjects: Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - isolation & purification; Anti-Bacterial Agents - pharmacology; antibacterial properties; Aspergillus - chemistry; Aspergillus terreus; carbon; chemical reactions; chemical structure; Chemistry; Chemistry, Organic; Circular Dichroism; circular dichroism spectroscopy; Crystallography, X-Ray; cytotoxicity; endophytes; fungi; Molecular Structure; organic compounds; Physical Sciences; Rhizophoraceae - microbiology; Science & Technology; Sesterterpenes - chemistry; Sesterterpenes - isolation & purification; Sesterterpenes - pharmacology; X-ray diffraction; SPONGE; MARINE ORGANISMS; PHORBAS
• ISSN: 1523-7060; 1523-7052; 1523-7052
• DOI: 10.1021/acs.orglett.6b00336

Two new sesterterpenoids, aspterpenacids A (1) and B (2), with an unusual carbon skeleton of a 5/3/7/6/5 ring system were isolated from the mangrove endophytic fungus Aspergillus terreus H010. Their structures were elucidated on the basis of spectroscopic methods, single-crystal X-ray diffraction analysis, and electronic circular dichroism calculations. A biogenetic pathway for 1 and 2 is proposed. Both 1 and 2 showed no significant antibacterial activity or cytotoxicity at 50 μM.