Efficacy of oncolytic virus in the treatment of intermediate-to-advanced solid tumors: a systematic review and meta-analysis

Although previous meta-analyses on this topic have been published, our research addresses the limitations of previous studies by including missed and newly published studies, updating the results, and conducting extensive subgroup analyses. Our study fills a gap in the literature by providing a comp...

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Published inJournal of virology Vol. 99; no. 7; p. e0064025
Main Authors Xu, Jin-Zhou, Sun, Jian-Xuan, Liu, Chen-Qian, Pan, Ruo-Yan, Zeng, Na, Zhang, Si-Han, An, Ye, Xu, Meng-Yao, Zhong, Xing-Yu, Ma, Si-Yang, He, Hao-Dong, Hu, Jia, Wang, Shao-Gang, Xia, Qi-Dong
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 22.07.2025
Subjects
Cellular Response to Infection
Humans
Neoplasms - therapy
Oncolytic Virotherapy - methods
Oncolytic Viruses - physiology
Treatment Outcome
Virology
meta-analysis
oncolytic virus
intermediate-to-advanced solid tumor
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Summary:Although previous meta-analyses on this topic have been published, our research addresses the limitations of previous studies by including missed and newly published studies, updating the results, and conducting extensive subgroup analyses. Our study fills a gap in the literature by providing a comprehensive evaluation of the therapeutic potential of oncolytic viruses for solid tumors.
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The authors declare no conflict of interest.
Jin-Zhou Xu, Jian-Xuan Sun, and Chen-Qian Liu contributed equally to this article. Author order was determined by drawing straws.
ISSN:0022-538X
1098-5514
1098-5514
DOI:10.1128/jvi.00640-25