Thalibealine, a Novel Tetrahydroprotoberberine−Aporphine Dimeric Alkaloid from Thalictrum wangii

• Published in: Journal of natural products (Washington, D.C.) Vol. 64; no. 6; pp. 819 - 822
• Main Authors: Al-Howiriny, Tawfeq A, Zemaitis, Michael A, Gao, Cong-yuan, Hadden, Chad E, Martin, Gary E, Lin, Fu-tyan, Schiff, Paul L
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 01.06.2001; Amer Chemical Soc; American Society of Pharmacognosy
• Subjects: Berberine Alkaloids - chemistry; Biological and medical sciences; Chemistry, Medicinal; China; Chromatography, Thin Layer; General pharmacology; Life Sciences & Biomedicine; Magnetic Resonance Spectroscopy; Medical sciences; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Plant Roots - chemistry; Plant Sciences; Plants, Medicinal - chemistry; Science & Technology; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Asia; China; Ether; Root; Angular nitrogen heterocycle; Pharmacognosy; Ranunculaceae; Oriental medicine; Tetracyclic compound; Berbin derivatives; Medicinal plant; Alkaloid; Folk medicine; Dicotyledones; Angiospermae; Plant origin; Isolation; Spermatophyta; Aromatic compound; Structural analysis; Enantiomer(-)
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np010095y

A novel tetrahydroprotoberberine−aporphine dimeric alkaloid, (−)-thalibealine (1), was isolated from the roots of Thalictrum wangiii, and its structure established via spectroscopic analysis. Three other alkaloids were isolated, including the benzyltetrahydroisoquinoline−aporphine dimer (+)-thalmelatidine, the aporphine (+)-magnoflorine, and the protoberberine berberine. This is the first reported isolation of a tetrahydroprotoberberine−aporphine dimer from nature, as well as the first reported isolation of constituents from Thalictrum wangii.