Chemistry and Biology of Ramoplanin:  A Lipoglycodepsipeptide with Potent Antibiotic Activity

• Published in: Chemical reviews Vol. 105; no. 2; pp. 449 - 476
• Main Authors: Walker, Suzanne, Chen, Lan, Hu, Yanan, Rew, Yosup, Shin, Dongwoo, Boger, Dale L
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 01.02.2005
• Subjects: Anti-Bacterial Agents - chemical synthesis; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antibiotics; Bacterial Outer Membrane Proteins - antagonists & inhibitors; Depsipeptides - chemical synthesis; Depsipeptides - chemistry; Depsipeptides - pharmacology; Gram-Positive Bacteria - drug effects; Gram-Positive Bacteria - enzymology; Microbial Sensitivity Tests; Molecular Structure; N-Acetylglucosaminyltransferases - antagonists & inhibitors; Structure-Activity Relationship
• ISSN: 0009-2665; 1520-6890
• DOI: 10.1021/cr030106n

Walker et. al discuss an antibiotic that belongs to a new structural class of compounds and has not shown any cross-resistance to other antibacterial agents. This antibiotic, ramoplanin, is currently in Phase III clinical trials for the prevention of vancomycin-resistant enterococcal infections in hospitalized patients, and it possesses some potentially important advantages over many other antibiotics.