Prediction of Membrane Protein Types by Incorporating Amphipathic Effects
According to their intramolecular arrangement and position in a cell, membrane proteins are generally classified into the following six types: (1) type I transmembrane, (2) type II transmembrane, (3) multipass transmembrane, (4) lipid chain-anchored membrane, (5) GPI-anchored membrane, and (6) peri...
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Published in | Journal of chemical information and modeling Vol. 45; no. 2; pp. 407 - 413 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
United States
American Chemical Society
01.03.2005
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Subjects | |
Online Access | Get full text |
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Summary: | According to their intramolecular arrangement and position in a cell, membrane proteins are generally classified into the following six types: (1) type I transmembrane, (2) type II transmembrane, (3) multipass transmembrane, (4) lipid chain-anchored membrane, (5) GPI-anchored membrane, and (6) peripheral membrane. Situated in a heteropolar environment, these six types of membrane proteins must have quite different amphiphilic sequence-order patterns in order to stabilize their respective frameworks. To incorporate such a feature into the predictor, the amphiphilic pseudo amino acid composition has been formulated that contains a series of hydrophobic and hydrophilic correlation factors. The success rates thus obtained have been remarkably enhanced in identifying the types of membrane proteins, as demonstrated by the jackknife test and independent data set test, respectively. |
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Bibliography: | ark:/67375/TPS-83Z0W7X1-K istex:EAD34F67BC81E904A969C8BD56A18E34B12809D4 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1549-9596 1549-960X |
DOI: | 10.1021/ci049686v |