Tunneling and Dynamics in Enzymatic Hydride Transfer

Enzymes continue to be the subject of intensive research efforts because of their ability to accelerate chemical reactions by factors as large as 1020 with extraordinary selectivity. Insight into recent advances in the field of enzymology, with emphasis on experiments illuminating the role of protei...

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Bibliographic Details
Published inChemical reviews Vol. 106; no. 8; pp. 3095 - 3118
Main Authors Nagel, Zachary D, Klinman, Judith P
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 01.08.2006
Subjects
Alcohol Dehydrogenase - chemistry
Alcohol Dehydrogenase - metabolism
Animals
Biochemistry
Catalysis
Chemical reactions
Enzymes
Glucose Oxidase - chemistry
Glucose Oxidase - metabolism
Hydrogen
Hydrogen - chemistry
Kinetics
Models, Chemical
Models, Molecular
Protein Binding
Protein Conformation
Proteins
Tetrahydrofolate Dehydrogenase - chemistry
Tetrahydrofolate Dehydrogenase - metabolism
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Summary:Enzymes continue to be the subject of intensive research efforts because of their ability to accelerate chemical reactions by factors as large as 1020 with extraordinary selectivity. Insight into recent advances in the field of enzymology, with emphasis on experiments illuminating the role of protein dynamics from the richly informative perspective of hydride transfer is presented.
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ISSN:0009-2665
1520-6890
DOI:10.1021/cr050301x