A “Traceless” Staudinger Ligation for the Chemoselective Synthesis of Amide Bonds

Here we report a novel modification of our previously reported “Staudinger ligation” that generates an amide bond from an azide and a specifically functionalized phosphine. This method for the selective formation of an amide bond, which does not require the orthogonal protection of distal functional...

Full description

Saved in:
Bibliographic Details
Published inOrganic letters Vol. 2; no. 14; pp. 2141 - 2143
Main Authors Saxon, Eliana, Armstrong, Joshua I, Bertozzi, Carolyn R
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 13.07.2000
Amer Chemical Soc
Subjects
Amides - chemical synthesis
Amides - chemistry
Chemistry
Chemistry, Organic
Chromatography, High Pressure Liquid
Indicators and Reagents
Molecular Conformation
Physical Sciences
Science & Technology
OLIGOSACCHARIDES
PEPTIDES
PROTEINS
ANALOGS
Online AccessGet full text

Cover

More Information
Summary:Here we report a novel modification of our previously reported “Staudinger ligation” that generates an amide bond from an azide and a specifically functionalized phosphine. This method for the selective formation of an amide bond, which does not require the orthogonal protection of distal functional groups, should find general utility in synthetic and biological chemistry.
Bibliography:Medline
NIH RePORTER
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1523-7060
1523-7052
DOI:10.1021/ol006054v