Microbial Transformation of Hypoestenone

Preparative-scale fermentation of hypoestenone (1) with Mucor raman nianus (ATCC 9628) has resulted in the isolation of 8(9)α-epoxyhypoestenone (2) and the new metabolites 8(9)α-epoxy-12,13-anhydrohypoestenone (3), 17-hydroxyhypoestenone (4), 13α,18-dihydroxyhypoestenone (5), and 13β,18-dihydroxyhyp...

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Bibliographic Details
Published inJournal of natural products (Washington, D.C.) Vol. 64; no. 3; pp. 373 - 375
Main Author El Sayed, Khalid A
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 01.03.2001
Amer Chemical Soc
American Society of Pharmacognosy
Subjects
Bioconversions. Hemisynthesis
Biological and medical sciences
Biotechnology
Biotransformation
Chemistry, Medicinal
Diterpenes - chemistry
Diterpenes - metabolism
Fundamental and applied biological sciences. Psychology
Life Sciences & Biomedicine
Magnetic Resonance Spectroscopy
Magnoliopsida
Methods. Procedures. Technologies
Mucor - metabolism
Pharmacology & Pharmacy
Plant Extracts - metabolism
Plant Sciences
Science & Technology
METABOLISM
Terpenoid
Mucor ramannianus
Hydroxylation
Phycomycetes
Tricyclic compound
Ketone
Fungi
Biotransformation
Diterpene
Epoxidation
Enone
Thallophyta
Enzymatic reaction
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Summary:Preparative-scale fermentation of hypoestenone (1) with Mucor raman nianus (ATCC 9628) has resulted in the isolation of 8(9)α-epoxyhypoestenone (2) and the new metabolites 8(9)α-epoxy-12,13-anhydrohypoestenone (3), 17-hydroxyhypoestenone (4), 13α,18-dihydroxyhypoestenone (5), and 13β,18-dihydroxyhypoestenone (6). Structure elucidation of these metabolites was based primarily on 1D and 2D NMR analyses.
Bibliography:ark:/67375/TPS-J6HM1FWV-S
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ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0163-3864
1520-6025
DOI:10.1021/np0005255