A Novel Three-Component One-Pot Pyrimidine Synthesis Based upon a Coupling−Isomerization Sequence

2,4,6-Tri(hetero)aryl-substituted pyrimidines can be readily synthesized in a three-component one-pot process based upon a coupling−isomerization sequence of an electron-poor (hetero)aryl halide and a terminal propargyl alcohol subsequently followed by a cyclocondensation with amidinium salts.

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Bibliographic Details
Published inOrganic letters Vol. 2; no. 13; pp. 1967 - 1970
Main Authors Müller, Thomas J. J, Braun, Roland, Ansorge, Markus
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 29.06.2000
Amer Chemical Soc
Subjects
Biochemistry - methods
Chemistry
Chemistry, Organic
Physical Sciences
Pyrimidines - chemical synthesis
Science & Technology
CHEMISTRY
MOLECULAR-SCALE WIRES
ANTIFUNGAL
COORDINATION ARRAYS
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Summary:2,4,6-Tri(hetero)aryl-substituted pyrimidines can be readily synthesized in a three-component one-pot process based upon a coupling−isomerization sequence of an electron-poor (hetero)aryl halide and a terminal propargyl alcohol subsequently followed by a cyclocondensation with amidinium salts.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1523-7060
1523-7052
DOI:10.1021/ol006046e