Biocellulose Membranes as Supports for Dermal Release of Lidocaine

• Published in: Biomacromolecules Vol. 12; no. 11; pp. 4162 - 4168
• Main Authors: Trovatti, Eliane, Silva, Nuno H. C. S., Duarte, Iola F., Rosado, Catarina F., Almeida, Isabel F., Costa, Paulo, Freire, Carmen S. R., Silvestre, Armando J. D., Neto, Carlos Pascoal
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 14.11.2011
• Subjects: Administration, Cutaneous; Adsorption; Applied sciences; Biological and medical sciences; Cellulose - chemistry; Drug Carriers - chemistry; Elastic Modulus; Epidermis - chemistry; Exact sciences and technology; Exchange resins and membranes; Forms of application and semi-finished materials; General pharmacology; Humans; Lidocaine - chemistry; Medical sciences; Membranes, Artificial; Permeability; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Polymer industry, paints, wood; Surface Properties; Technology of polymers; Tensile Strength; Transport properties; Transdermal system; Swelling; Control release polymer; Cellulose; Mechanical properties; Glycerol; Drug carrier; Tensile property; Permeability; Experimental study; Local anesthetic; Microbial origin; Molecular mobility; Morphology; Membrane; Kinetics; Lidocaine; Release
• ISSN: 1525-7797; 1526-4602
• DOI: 10.1021/bm201303r

Biocellulose (BC) is a highly pure form of cellulose, produced in the form of a swollen membrane, with several applications in the biomedical area. In this study, the behavior of BC membranes as systems for topical delivery of lidocaine was evaluated. The BC-lidocaine membranes were prepared and characterized in terms of structural and morphological properties. A uniform distribution of the drug inside the BC membranes was observed. In vitro diffusion studies with Franz cells were conducted using human epidermal membranes and showed that the permeation rate of the drug in BC membranes was slightly slower than that obtained with the conventional systems, which was attributed to the establishment of interactions between the lidocaine molecules and the BC membrane, as evidenced by FTIR and NMR analysis. These results indicate that this methodology can be successfully applied for the dermal administration of lidocaine regarding the release profile and ease of application.