Efficient Enantioselective Additions of Terminal Alkynes and Aldehydes under Operationally Convenient Conditions

The enantioselective addition reaction of terminal acetylenes and aldehydes mediated by Zn(OTf)2 and N-methyl ephedrine can be conducted with reagent grade solvent containing 84−1000 ppm H2O. The products can be isolated in high yield and useful enantioselectivities (up to 99% ee).

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Bibliographic Details
Published inOrganic letters Vol. 4; no. 15; pp. 2605 - 2606
Main Authors Boyall, Dean, Frantz, Doug E, Carreira, Erick M
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 25.07.2002
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
MILD
ACETYLENES
FACILE
IN-SITU GENERATION
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Summary:The enantioselective addition reaction of terminal acetylenes and aldehydes mediated by Zn(OTf)2 and N-methyl ephedrine can be conducted with reagent grade solvent containing 84−1000 ppm H2O. The products can be isolated in high yield and useful enantioselectivities (up to 99% ee).
Bibliography:ObjectType-Article-1
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ISSN:1523-7060
1523-7052
DOI:10.1021/ol026282k