Highly Enantioselective Additions of Diethylzinc to Aldehydes Using 2-Triflamido-methyl-2‘-hydroxy-1,1‘- binaphthyl

A new N-triflated amino alcohol−titanium catalyst was designed for the asymmetric ethylation of aldehydes. This binaphthyl-based sulfonamido alcohol ligand shows uniformly high yield and enantioselectivity in the diethylzinc additions of aromatic, aliphatic, and unsaturated aldehydes.

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Bibliographic Details
Published inOrganic letters Vol. 5; no. 23; pp. 4517 - 4519
Main Authors Kang, Seung-Wan, Ko, Dong-Hyun, Kim, Kyoung Hoon, Ha, Deok-Chan
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 13.11.2003
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
COMPLEX
REAGENTS
LIGANDS
ALKYLATION
DIALKYLZINC
TITANIUM
DERIVATIVES
CATALYSTS
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Summary:A new N-triflated amino alcohol−titanium catalyst was designed for the asymmetric ethylation of aldehydes. This binaphthyl-based sulfonamido alcohol ligand shows uniformly high yield and enantioselectivity in the diethylzinc additions of aromatic, aliphatic, and unsaturated aldehydes.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1523-7060
1523-7052
DOI:10.1021/ol0358511