Bioactivities of Glycoalkaloids and Their Aglycones from Solanum Species

• Published in: Journal of agricultural and food chemistry Vol. 59; no. 8; pp. 3454 - 3484
• Main Authors: Milner, Sinead Eileen, Brunton, Nigel Patrick, Jones, Peter Wyn, O’ Brien, Nora Mary, Collins, Stuart Gerard, Maguire, Anita Rose
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 27.04.2011
• Subjects: Alkaloids; Alkaloids - chemistry; Alkaloids - pharmacology; bioavailability; Biological and medical sciences; Carbohydrates; Carbohydrates - chemistry; Carbohydrates - pharmacology; chemical structure; chemistry; Crops, Agricultural; Crops, Agricultural - chemistry; cultivars; eggplants; Food industries; Food Safety; Fundamental and applied biological sciences. Psychology; glycoalkaloids; Hydrolysis; lectins; Magnetic Resonance Spectroscopy; Mass Spectrometry; pharmacology; phenolic compounds; potatoes; secondary metabolites; Solanum; Solanum - chemistry; synergism; tomatoes; toxicity; synergism; structure−activity relationship; glycoalkaloids; aglycones; anticancer; Antineoplastic agent; Aglycone; Synergism; Structure activity relation; Dicotyledones; Angiospermae; Spermatophyta; Solanaceae; Solanum; Species; structure—activity relationship
• ISSN: 0021-8561; 1520-5118; 1520-5118
• DOI: 10.1021/jf200439q

Potatoes, tomatoes, and aubergines are all species of the Solanum genus and contain a vast array of secondary metabolites including calystegine alkaloids, phenolic compounds, lectins, and glycoalkaloids. Glycoalkaloids have been the subject of many literature papers, occur widely in the human diet, and are known to induce toxicity. Therefore, from a food safety perspective further information is required regarding their analysis, toxicity, and bioavailability. This is especially important in crop cultivars derived from wild species to prevent glycoalkaloid-induced toxicity. A comprehensive review of the bioactivity of glycoalkaloids and their aglycones of the Solanum species, particularly focused on comparison of their bioactivities including their anticancer, anticholesterol, antimicrobial, anti-inflammatory, antinociceptive, and antipyretic effects, toxicity, and synergism of action of the principal Solanum glycoalkaloids, correlated to differences of their individual molecular structures is presented.