Bogorol A Produced in Culture by a Marine Bacillus sp. Reveals a Novel Template for Cationic Peptide Antibiotics

Bogorol A (1), a novel peptide antibiotic active against MRSA and VRE, has been isolated from cultures of a marine Bacillus sp. collected in Papua New Guinea. The structure of bogorol A was elucidated by a combination of spectroscopic analyses and chemical degradation. Bogorol A illustrates a new st...

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Bibliographic Details
Published inOrganic letters Vol. 3; no. 3; pp. 437 - 440
Main Authors Barsby, Todd, Kelly, Michael T, Gagné, Stéphane M, Andersen, Raymond J
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 08.02.2001
Amer Chemical Soc
Subjects
Anti-Bacterial Agents - biosynthesis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Bacillus - metabolism
Cations
Chemistry
Chemistry, Organic
Enterococcus - drug effects
Magnetic Resonance Spectroscopy
Methicillin Resistance
Microbial Sensitivity Tests
Peptides
Physical Sciences
Science & Technology
Spectrometry, Mass, Fast Atom Bombardment
Staphylococcus aureus - drug effects
Templates, Genetic
Vancomycin Resistance
RESISTANCE
BACTERIUM
HELIX
DEFENSINS
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Summary:Bogorol A (1), a novel peptide antibiotic active against MRSA and VRE, has been isolated from cultures of a marine Bacillus sp. collected in Papua New Guinea. The structure of bogorol A was elucidated by a combination of spectroscopic analyses and chemical degradation. Bogorol A illustrates a new structural template for “cationic peptide antibiotics”.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1523-7060
1523-7052
DOI:10.1021/ol006942q