Lab-in-a-Tube: Detection of Individual Mouse Cells for Analysis in Flexible Split-Wall Microtube Resonator Sensors

We report a method for the precise capturing of embryonic fibroblast mouse cells into rolled-up microtube resonators. The microtubes contain a nanometer-sized gap in their wall which defines a new type of optofluidic sensor, i.e., a flexible split-wall microtube resonator sensor, employed as a label...

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Published inNano letters Vol. 11; no. 10; pp. 4037 - 4042
Main Authors Smith, Elliot J, Schulze, Sabine, Kiravittaya, Suwit, Mei, Yongfeng, Sanchez, Samuel, Schmidt, Oliver G
Format Journal Article
LanguageEnglish
Published Washington, DC American Chemical Society 12.10.2011
Subjects
Exact sciences and technology
Fibroblasts
General equipment and techniques
Illumination
Instruments, apparatus, components and techniques common to several branches of physics and astronomy
Nanostructure
Physics
Resonators
Sensors
Sensors (chemical, optical, electrical, movement, gas, etc.); remote sensing
Spectra
Walls
Whispering gallery modes
nanomembrane
rolled-up
microsyringe
lab-in-a-tube
Biosensor
optical resonator
Fibroblasts
Illumination
Sensors
Gallium phosphide
Spectral line shift
Resonators
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Summary:We report a method for the precise capturing of embryonic fibroblast mouse cells into rolled-up microtube resonators. The microtubes contain a nanometer-sized gap in their wall which defines a new type of optofluidic sensor, i.e., a flexible split-wall microtube resonator sensor, employed as a label-free fully integrative detection tool for individual cells. The sensor action works through peak sharpening and spectral shifts of whispering gallery modes within the microresonators under light illumination.
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ISSN:1530-6984
1530-6992
DOI:10.1021/nl1036148