Spectrophotometric Investigations of Macrolide Antibiotics: A Brief Review

Macrolides, one of the most commonly used class of antibiotics, are a group of drugs produced by Streptomyces species. They belong to the polyketide class of natural products. Their activity is due to the presence of a large macrolide lactone ring with deoxy sugar moieties. They are protein synthesi...

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Bibliographic Details
Published inAnalytical Chemistry Insights Vol. 2015; no. 10; pp. 41 - 49
Main Authors Keskar, Mrudul R., Jugade, Ravin M.
Format Journal Article Book Review
LanguageEnglish
Published London, England Libertas Academica 01.01.2015
SAGE Publishing
SAGE Publications
Subjects
Review
Macrolide antibiotics
spectrophotometric analysis
ion pair complexes
charge transfer complexes
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Summary:Macrolides, one of the most commonly used class of antibiotics, are a group of drugs produced by Streptomyces species. They belong to the polyketide class of natural products. Their activity is due to the presence of a large macrolide lactone ring with deoxy sugar moieties. They are protein synthesis inhibitors and broad-spectrum antibiotics, active against both gram-positive and gram-negative bacteria. Different analytical techniques have been reported for the determination of macrolides such as chromatographic methods, flow injection methods, spectrofluorometric methods, spectrophotometric methods, and capillary electrophoresis methods. Among these methods, spectrophotometric methods are sensitive and cost effective for the analysis of various antibiotics in pharmaceutical formulations as well as biological samples. This article reviews different spectrophotometric methods for the determination of macrolide antibiotics.
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ISSN:1177-3901
1177-3901
DOI:10.4137/ACI.S31857