A Single Fluorescent Chemosensor for Simultaneous Discriminative Detection of Gaseous Phosgene and a Nerve Agent Mimic

• Published in: Analytical chemistry (Washington) Vol. 91; no. 18; pp. 12070 - 12076
• Main Authors: Zeng, Lintao, Zeng, Hongyan, Jiang, Lirong, Wang, Shan, Hou, Ji-Ting, Yoon, Juyoung
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 17.09.2019
• Subjects: Analytical chemistry; Anthracene; Biological & chemical weapons; Chemical sensors; Chemistry; Chemoreceptors; Colorimetry; Fluorescence; Nerve agents; o-Phenylenediamine; Phenylenediamine; Phosgene; Phosphorylation; Selectivity
• ISSN: 0003-2700; 1520-6882
• DOI: 10.1021/acs.analchem.9b03230

A fluorescent chemosensor has been developed for discriminative detection of phosgene and a nerve agent mimic diethyl chlorophosphate (DCP), which was comprised of an anthracene-carboxyimide fluorophore and o-phenylenediamine (OPD) reaction site. Upon phosphorylation of OPD, the chemosensor displays an obvious fluorescence turn-on response toward DPC at 588 nm with instant response and a low detection limit (88 nM). By contrast, the chemosensor exhibits a colorimetric and fluorescence enhancement response at 500 nm toward phosgene with fast response (<2 min), high selectivity, and a low detection limit (72 nM). Furthermore, chemosensor-loaded test membrane was fabricated for real-time, portable and efficient discriminative detection of trace amounts of gaseous phosgene and DCP vapor with different optical responses.