FeLIX is a restriction factor for mammalian retrovirus infection

• Published in: Journal of virology Vol. 98; no. 4; p. e0177123
• Main Authors: Pramono, Didik, Takeuchi, Dai, Katsuki, Masato, AbuEed, Loai, Abdillah, Dimas, Kimura, Tohru, Kawasaki, Junna, Miyake, Ariko, Nishigaki, Kazuo
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 16.04.2024
• Subjects: Veterinary Microbiology; Virus-Cell Interactions; restriction factor; endogenous retrovirus; feline leukemia virus

Retroviruses are unique in using reverse transcriptase to convert RNA genomes into DNA, infecting germ cells, and transmitting to offspring. Numerous ancient retroviral sequences are known as endogenous retroviruses (ERVs). The soluble Env protein derived from ERVs functions as a co-factor that assi...