Efficient Chiral Nanosenor Based on Tip-Modified Nanochannels

Enantiomers of various drug molecules have a specific effect on living organisms. Accordingly, developing a sample method for the efficient and rapid recognition of chiral drug enantiomers is of great industrial value and physiological significance. Here, inspired by the structure of ion channels in...

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Published inAnalytical chemistry (Washington) Vol. 93; no. 15; pp. 6145 - 6150
Main Authors Wang, Yingqian, Zhang, Siyun, Yan, Hewei, Quan, Jiaxin, Yang, Lei, Chen, Xue, Toimil-Molares, Maria Eugenia, Trautmann, Christina, Li, Haibing
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 20.04.2021
Subjects
Alanine
Analytical chemistry
Aromatic compounds
Chemistry
Enantiomers
Ion channels
L-Alanine
Nanochannels
Propranolol
Recognition
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Summary:Enantiomers of various drug molecules have a specific effect on living organisms. Accordingly, developing a sample method for the efficient and rapid recognition of chiral drug enantiomers is of great industrial value and physiological significance. Here, inspired by the structure of ion channels in living organisms, we developed a chiral nanosensor based on an artificial tip-modified nanochannel system that allows efficient selective recognition of chiral drugs. In this system, l-alanine-pillar­[5]­arenes as selective receptors were introduced on the tip side of conical nanochannels to form an enantioselective “gate”. The selective coefficient of our system toward R-propranolol is 4.96, which is higher than the traditional fully modified nanochannels in this work.
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ISSN:0003-2700
1520-6882
DOI:10.1021/acs.analchem.0c05390