Time-Gated Imaging of Latent Fingerprints and Specific Visualization of Protein Secretions via Molecular Recognition

Persistent nanophosphors can remain luminescent after excitation ceases; thus, they offer a promising way to avoid background fluorescence interference in bioimaging. In this work, Zn2GeO4:Ga,Mn (ZGO:Ga,Mn) persistent luminescence nanoparticles were developed and they were employed for time-gated im...

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Published inAnalytical chemistry (Washington) Vol. 89; no. 23; pp. 12764 - 12770
Main Authors Wang, Jie, Ma, Qinqin, Liu, Haoyang, Wang, Yingqian, Shen, Haijing, Hu, Xiaoxia, Ma, Chao, Yuan, Quan, Tan, Weihong
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 05.12.2017
Subjects
Adult
Amino acids
Amino Acids - chemistry
Carboxyl group
Chemistry
Concanavalin A
Concanavalin A - chemistry
Dermatoglyphics
Female
Fingerprints
Fluorescence
Forensic science
Forensic Sciences - methods
Gallium - chemistry
Germanium - chemistry
Glycoproteins
Glycoproteins - chemistry
Humans
Luminescence
Luminescent Agents - chemistry
Male
Manganese - chemistry
Medical imaging
Metal Nanoparticles - chemistry
Nanoparticles
Nanophosphors
Oxides - chemistry
Secretions
Visualization
Young Adult
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Summary:Persistent nanophosphors can remain luminescent after excitation ceases; thus, they offer a promising way to avoid background fluorescence interference in bioimaging. In this work, Zn2GeO4:Ga,Mn (ZGO:Ga,Mn) persistent luminescence nanoparticles were developed and they were employed for time-gated imaging of latent fingerprints (LFP). The nanoparticles were functionalized with a carboxyl group and utilized to label LFP through reacting with the amino group in the LFP. Results proved the potent ability of ZGO:Ga,Mn in eliminating background fluorescence to afford highly sensitive LFP imaging. Moreover, LFP aged for 60 days were successfully detected due to the presence of highly stable amino acids. After being functionalized with concanavalin A, the nanoparticles achieved visualization of glycoproteins in LFP. This strategy provides great versatility in LFP imaging and good potential in uncovering the chemical information within LFP, making it valuable in forensic investigations and medical diagnostics.
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ISSN:0003-2700
1520-6882
DOI:10.1021/acs.analchem.7b03003