Macrocyclic Lactam Synthesis via a Ring Expansion Reaction:  Construction of the Cripowellin Skeleton

The cripowellin ring skeleton, a macrocyclic [2.3.5]-bicyclic ketolactam, was smoothly generated via construction of a spiro(benzazepin-cyclohexane-1,3-dione) employing oxidative cyclization as a key step and a subsequent ring expansion reaction.

Saved in:
Bibliographic Details
Published inOrganic letters Vol. 7; no. 6; pp. 1031 - 1034
Main Authors Moon, Bongjin, Han, Sangbae, Yoon, Yeojin, Kwon, Hyejin
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 17.03.2005
Amer Chemical Soc
Subjects
Amaryllidaceae Alkaloids - chemical synthesis
Amaryllidaceae Alkaloids - chemistry
Catalysis
Chemistry
Chemistry, Organic
Cyclization
Indicators and Reagents
Lactams, Macrocyclic - chemical synthesis
Molecular Structure
Oxidation-Reduction
Physical Sciences
Plants, Medicinal - chemistry
Science & Technology
CONVENIENT SYNTHESIS
AMARYLLIDACEAE ALKALOIDS
ANNULATION
HYPERVALENT IODINE(III) REAGENT
DERIVATIVES
PHENOLIC COUPLING REACTION
CYCLIZATION
Online AccessGet full text

Cover

More Information
Summary:The cripowellin ring skeleton, a macrocyclic [2.3.5]-bicyclic ketolactam, was smoothly generated via construction of a spiro(benzazepin-cyclohexane-1,3-dione) employing oxidative cyclization as a key step and a subsequent ring expansion reaction.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1523-7060
1523-7052
DOI:10.1021/ol047520+