Thermosensitive Hydrogels as Scaffolds for Cartilage Tissue Engineering

• Published in: Biomacromolecules Vol. 20; no. 4; pp. 1478 - 1492
• Main Authors: Zhang, Yanbo, Yu, Jiakuo, Ren, Kaixuan, Zuo, Jianlin, Ding, Jianxun, Chen, Xuesi
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 08.04.2019
• Subjects: allografting; Animals; blood; cartilage; Cartilage, Articular - injuries; Cartilage, Articular - metabolism; Cartilage, Articular - pathology; Chondrocytes - metabolism; Chondrocytes - pathology; Chondrogenesis; Extracellular Matrix - chemistry; hydrogels; Hydrogels - chemistry; Hydrogels - therapeutic use; nutrients; osteoarthritis; pain; physical properties; prognosis; stem cells; thermosensitivity; Tissue Engineering; Tissue Scaffolds - chemistry

Articular cartilage defects, caused by trauma, osteoarthritis, or other diseases, always lead to severe joint pain and joint dysfunction. Without access to progenitor cells and the supply of blood and nutrients, the impaired articular cartilage would be short of the capability to self-repair. Althou...