Thermosensitive Hydrogels as Scaffolds for Cartilage Tissue Engineering

Articular cartilage defects, caused by trauma, osteoarthritis, or other diseases, always lead to severe joint pain and joint dysfunction. Without access to progenitor cells and the supply of blood and nutrients, the impaired articular cartilage would be short of the capability to self-repair. Althou...

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Published inBiomacromolecules Vol. 20; no. 4; pp. 1478 - 1492
Main Authors Zhang, Yanbo, Yu, Jiakuo, Ren, Kaixuan, Zuo, Jianlin, Ding, Jianxun, Chen, Xuesi
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 08.04.2019
Subjects
allografting
Animals
blood
cartilage
Cartilage, Articular - injuries
Cartilage, Articular - metabolism
Cartilage, Articular - pathology
Chondrocytes - metabolism
Chondrocytes - pathology
Chondrogenesis
Extracellular Matrix - chemistry
hydrogels
Hydrogels - chemistry
Hydrogels - therapeutic use
nutrients
osteoarthritis
pain
physical properties
prognosis
stem cells
thermosensitivity
Tissue Engineering
Tissue Scaffolds - chemistry
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Abstract Articular cartilage defects, caused by trauma, osteoarthritis, or other diseases, always lead to severe joint pain and joint dysfunction. Without access to progenitor cells and the supply of blood and nutrients, the impaired articular cartilage would be short of the capability to self-repair. Although the present clinical treatments, including autogenous and allograft osteochondral transplantation, microfracture technique, and so forth, have shown some efficacies, their drawbacks, such as donor insufficiency and poor-integration with adjacent tissue, limit the satisfactory repair of articular cartilage defects and cause unsatisfied prognosis. Cartilage tissue engineering, involving the combination of progenitor cells with scaffolds, which serve as artificial extracellular matrices (ECMs), provides a promising strategy for cartilage regeneration. Recently, thermosensitive hydrogels have attracted much attention as scaffolds for cartilage tissue engineering owing to their unique physical properties analogous to the native ECM. In this review, we summarize the fabrication, characterization of newly reported thermosensitive hydrogels as cartilage tissue engineering scaffolds. The potential challenges and future perspectives are proposed.
AbstractList Articular cartilage defects, caused by trauma, osteoarthritis, or other diseases, always lead to severe joint pain and joint dysfunction. Without access to progenitor cells and the supply of blood and nutrients, the impaired articular cartilage would be short of the capability to self-repair. Although the present clinical treatments, including autogenous and allograft osteochondral transplantation, microfracture technique, and so forth, have shown some efficacies, their drawbacks, such as donor insufficiency and poor-integration with adjacent tissue, limit the satisfactory repair of articular cartilage defects and cause unsatisfied prognosis. Cartilage tissue engineering, involving the combination of progenitor cells with scaffolds, which serve as artificial extracellular matrices (ECMs), provides a promising strategy for cartilage regeneration. Recently, thermosensitive hydrogels have attracted much attention as scaffolds for cartilage tissue engineering owing to their unique physical properties analogous to the native ECM. In this review, we summarize the fabrication, characterization of newly reported thermosensitive hydrogels as cartilage tissue engineering scaffolds. The potential challenges and future perspectives are proposed.
Articular cartilage defects, caused by trauma, osteoarthritis, or other diseases, always lead to severe joint pain and joint dysfunction. Without access to progenitor cells and the supply of blood and nutrients, the impaired articular cartilage would be short of the capability to self-repair. Although the present clinical treatments, including autogenous and allograft osteochondral transplantation, microfracture technique, and so forth, have shown some efficacies, their drawbacks, such as donor insufficiency and poor-integration with adjacent tissue, limit the satisfactory repair of articular cartilage defects and cause unsatisfied prognosis. Cartilage tissue engineering, involving the combination of progenitor cells with scaffolds, which serve as artificial extracellular matrices (ECMs), provides a promising strategy for cartilage regeneration. Recently, thermosensitive hydrogels have attracted much attention as scaffolds for cartilage tissue engineering owing to their unique physical properties analogous to the native ECM. In this review, we summarize the fabrication, characterization of newly reported thermosensitive hydrogels as cartilage tissue engineering scaffolds. The potential challenges and future perspectives are proposed.Articular cartilage defects, caused by trauma, osteoarthritis, or other diseases, always lead to severe joint pain and joint dysfunction. Without access to progenitor cells and the supply of blood and nutrients, the impaired articular cartilage would be short of the capability to self-repair. Although the present clinical treatments, including autogenous and allograft osteochondral transplantation, microfracture technique, and so forth, have shown some efficacies, their drawbacks, such as donor insufficiency and poor-integration with adjacent tissue, limit the satisfactory repair of articular cartilage defects and cause unsatisfied prognosis. Cartilage tissue engineering, involving the combination of progenitor cells with scaffolds, which serve as artificial extracellular matrices (ECMs), provides a promising strategy for cartilage regeneration. Recently, thermosensitive hydrogels have attracted much attention as scaffolds for cartilage tissue engineering owing to their unique physical properties analogous to the native ECM. In this review, we summarize the fabrication, characterization of newly reported thermosensitive hydrogels as cartilage tissue engineering scaffolds. The potential challenges and future perspectives are proposed.
Author Zhang, Yanbo
Chen, Xuesi
Zuo, Jianlin
Ding, Jianxun
Ren, Kaixuan
Yu, Jiakuo
AuthorAffiliation Jilin Biomedical Polymers Engineering Laboratory
Peking University Third Hospital
University of Southern California
Knee Surgery Department of the Institute of Sports Medicine
Mork Family Department of Chemical Engineering & Materials Science
Department of Orthopedics
China-Japan Union Hospital of Jilin University
AuthorAffiliation_xml – name: Peking University Third Hospital
– name: Department of Orthopedics
– name: China-Japan Union Hospital of Jilin University
– name: University of Southern California
– name: Knee Surgery Department of the Institute of Sports Medicine
– name: Jilin Biomedical Polymers Engineering Laboratory
– name: Mork Family Department of Chemical Engineering & Materials Science
Author_xml – sequence: 1
  givenname: Yanbo
  surname: Zhang
  fullname: Zhang, Yanbo
  organization: China-Japan Union Hospital of Jilin University
– sequence: 2
  givenname: Jiakuo
  surname: Yu
  fullname: Yu, Jiakuo
  organization: Peking University Third Hospital
– sequence: 3
  givenname: Kaixuan
  surname: Ren
  fullname: Ren, Kaixuan
  email: kaixuanr@usc.edu
  organization: University of Southern California
– sequence: 4
  givenname: Jianlin
  surname: Zuo
  fullname: Zuo, Jianlin
  email: jlzuojianlin@163.com
  organization: China-Japan Union Hospital of Jilin University
– sequence: 5
  givenname: Jianxun
  orcidid: 0000-0002-5232-8863
  surname: Ding
  fullname: Ding, Jianxun
  email: jxding@ciac.ac.cn
  organization: Jilin Biomedical Polymers Engineering Laboratory
– sequence: 6
  givenname: Xuesi
  orcidid: 0000-0003-3542-9256
  surname: Chen
  fullname: Chen, Xuesi
  organization: Jilin Biomedical Polymers Engineering Laboratory
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30843390$$D View this record in MEDLINE/PubMed
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Snippet Articular cartilage defects, caused by trauma, osteoarthritis, or other diseases, always lead to severe joint pain and joint dysfunction. Without access to...
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SubjectTerms allografting
Animals
blood
cartilage
Cartilage, Articular - injuries
Cartilage, Articular - metabolism
Cartilage, Articular - pathology
Chondrocytes - metabolism
Chondrocytes - pathology
Chondrogenesis
Extracellular Matrix - chemistry
hydrogels
Hydrogels - chemistry
Hydrogels - therapeutic use
nutrients
osteoarthritis
pain
physical properties
prognosis
stem cells
thermosensitivity
Tissue Engineering
Tissue Scaffolds - chemistry
Title Thermosensitive Hydrogels as Scaffolds for Cartilage Tissue Engineering
URI http://dx.doi.org/10.1021/acs.biomac.9b00043
https://www.ncbi.nlm.nih.gov/pubmed/30843390
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