Angiogenic Self-Assembling Peptide Scaffolds for Functional Tissue Regeneration

Implantation of acellular biomimetic scaffolds with proangiogenic motifs may have exciting clinical utility for the treatment of ischemic pathologies such as myocardial infarction. Although direct delivery of angiogenic proteins is a possible treatment option, smaller synthetic peptide-based nanostr...

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Bibliographic Details
Published inBiomacromolecules Vol. 19; no. 9; pp. 3597 - 3611
Main Authors Sarkar, Biplab, Nguyen, Peter K, Gao, William, Dondapati, Akhil, Siddiqui, Zain, Kumar, Vivek A
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 10.09.2018
Subjects
angiogenic proteins
biomimetics
epitopes
metabolism
moieties
myocardial infarction
peptides
tissue repair
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Summary:Implantation of acellular biomimetic scaffolds with proangiogenic motifs may have exciting clinical utility for the treatment of ischemic pathologies such as myocardial infarction. Although direct delivery of angiogenic proteins is a possible treatment option, smaller synthetic peptide-based nanostructured alternatives are being investigated due to favorable factors, such as sustained efficacy and high-density epitope presentation of functional moieties. These peptides may be implanted in vivo at the site of ischemia, bypassing the first-pass metabolism and enabling long-term retention and sustained efficacy. Mimics of angiogenic proteins show tremendous potential for clinical use. We discuss possible approaches to integrate the functionality of such angiogenic peptide mimics into self-assembled peptide scaffolds for application in functional tissue regeneration.
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ISSN:1525-7797
1526-4602
1526-4602
DOI:10.1021/acs.biomac.8b01137